A Simple VITAMIN May Be the Game-Changer For Mitochondrial Health?

Introducing Oscar, a 61-year-old diagnosed with a muscle weakness disease at the age of 30, limiting his walking distance to 200 meters.

Discussion on using a mouse model with a similar mitochondrial nuclear encoded twinkle helicase mutation like Oscar, leading to mitochondrial DNA delions accumulation.

Exploration of metabolites in muscle and the impact of vitamin B3 on regulating metabolic reactions, increasing NAD, and altering enzyme pathways.

Details of a trial using niacin on mice with the same mutation as Oscar, resulting in changes in body weight, muscle NAD levels, and metabolic activity.

Observations of decreased liver fat, muscle activity, and respiratory chain function in patients after nasin treatment, indicating potential metabolic improvements.

Efforts to develop a test for all patients with the condition to measure glutathione levels in blood samples for validation and treatment monitoring.

Discussion on the implementation of the testing system supported by a congress to analyze NAD levels in different blood components for optimal dosage determination.

Exploration of the effects of niaspan dosage on blood parameters like HBAC, HDL, and NAD, with findings indicating dose-dependent changes in glucose and glutathione levels.

Highlighting the need to identify and treat mitochondrial disorders by addressing metabolic deficiencies similar to providing vitamin B12 or D for deficiencies.

Discussion on evidence from human studies, including degenerative diseases like Parkinson's, showcasing the importance of detecting and addressing vitamin B3 deficiencies in mitochondrial disorders.