TWiV 1119: Gene editing latent herpes
Updated: November 13, 2025
Summary
The virology podcast, hosted by Vincent Racaniello, delves into various topics including the impact of viruses on health, new research papers on infections like monkeypox, and innovative gene editing approaches to combat herpes simplex virus. The podcast also touches upon upcoming virology events such as the International Hepatitis B Virus meeting in Chicago and provides insights into unique scientific phenomena like the mating behavior of anglerfish. Additionally, discussions on mRNA vaccines, viral shedding reduction using mega nucleases, and challenges in using rabies vaccines for wolf dogs offer a comprehensive look into the world of virology.
TABLE OF CONTENTS
Introduction to Virology Podcast
Weather Update
Meeting in Stockholm
Participants Joining from Different Locations
International Hepatitis B Virus Meeting
Special Events and Workshops
Research Papers on Monkeypox Virus
Nature Communications Papers
Gene Editing Research
AAV Experiment Toxicity
Reduction in Viral Shedding
Neurotropic Vectors and Hepatotoxicity
Herpes Virus Infection
Rabies Vaccine for Wolf Dogs
Anglerfish Reproduction
Virology Paper Queries
Scientific Discoveries and Articles
Introduction to Virology Podcast
Introduction to the virology podcast discussing viruses and their impact on health. The podcast is hosted by Vincent Racaniello.
Weather Update
Description of the weather conditions during the podcast recording, including temperature and sky conditions in different locations.
Meeting in Stockholm
Discussion about a meeting in Stockholm and the weather conditions there.
Participants Joining from Different Locations
Introduction of participants joining the podcast from various locations like Austin, Texas, and Finland.
International Hepatitis B Virus Meeting
Information about an upcoming International Hepatitis B virus meeting in Chicago, Illinois, with details on registration and abstract submission.
Special Events and Workshops
Announcement of special events and workshops at the meeting, including a workshop on speaking like a pro and other educational workshops.
Research Papers on Monkeypox Virus
Discussion of research papers on monkeypox virus, including characteristics of infection and immune responses in patients.
Nature Communications Papers
Summary of research papers published in Nature Communications on virus infection dynamics and antibody conversion in individuals infected with monkeypox virus.
Gene Editing Research
Overview of a study on gene editing in herpes simplex virus infections, targeting viral genes to reduce viral loads and shedding in mouse models.
AAV Experiment Toxicity
Discussion on the toxicity observed in experiments involving animals receiving AAV at different doses, leading to liver damage and neuronal issues.
Reduction in Viral Shedding
Exploration of the effectiveness of mega nucleases in reducing viral shedding and its impact on vaginally infected mice, with a trend towards a substantial reduction.
Neurotropic Vectors and Hepatotoxicity
Analysis of the use of neurotropic vectors in treating mice with high doses, showing a decrease in ganglionic viral loads and addressing the hepatotoxicity issue.
Herpes Virus Infection
Discussion on the ability of mega nucleases to edit herpes genomes and reduce shedding, impacting the transmission of the virus.
Rabies Vaccine for Wolf Dogs
Exploration of the challenges and considerations related to using the rabies vaccine for wolf dogs, highlighting the need for specific research into wolf immune systems.
Anglerfish Reproduction
Fascinating insights into the unique mating behavior of anglerfish, where males become parasites to females, leading to the disintegration of males over time.
Virology Paper Queries
Questions regarding self-replicating mRNA vaccines and their interaction with viral illnesses, exploring the potential impact on spike protein expression and virus maturation.
Scientific Discoveries and Articles
Sharing of interesting scientific findings, including a study on sea urchin mortality, a Facebook page on sunspot regions, and a discussion on unproductive meetings in organizations.
FAQ
Q: What are some topics discussed in the virology podcast?
A: The virology podcast covers discussions on viruses, their impact on health, weather conditions, research papers on various viruses like monkeypox and herpes simplex virus infections, gene editing in viruses, and the effectiveness of different treatments against viral infections.
Q: Can you provide information about the International Hepatitis B virus meeting mentioned in the file?
A: The International Hepatitis B virus meeting is set to take place in Chicago, Illinois. Details regarding registration and abstract submission are available. Furthermore, special events including workshops on speaking skills and educational workshops are planned for the meeting.
Q: What research papers are discussed in relation to monkeypox virus in the podcast?
A: The podcast delves into research papers published in Nature Communications that focus on virus infection dynamics and antibody conversion in individuals infected with monkeypox virus. Additionally, there is an overview of a study on gene editing in herpes simplex virus infections and its impacts on viral loads in mouse models.
Q: What is mentioned regarding the use of mega nucleases in treating viral infections like herpes and its effectiveness?
A: The podcast explores the use of mega nucleases in reducing viral shedding and impacts on vaginally infected mice. There is a discussion on their ability to edit herpes genomes, reduce shedding, and consequently affect the virus transmission.
Q: What unique mating behavior of anglerfish is discussed in the podcast?
A: The podcast discusses the unique mating behavior of anglerfish where males become parasites to females, eventually leading to the disintegration of the males over time.
Q: What scientific findings and topics outside virology are shared in the podcast?
A: Apart from virology, the podcast touches upon diverse scientific topics including sea urchin mortality studies, Facebook pages on sunspot regions, and insights on unproductive meetings within organizations.
Q: How is the interaction between self-replicating mRNA vaccines and viral illnesses explored in the podcast?
A: The podcast explores the interaction between self-replicating mRNA vaccines and viral illnesses in terms of their impact on spike protein expression and virus maturation.
Q: What are the challenges discussed regarding the use of the rabies vaccine for wolf dogs?
A: The challenges related to using the rabies vaccine for wolf dogs are discussed, emphasizing the need for specific research into wolf immune systems.
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